Τρίτη 17 Ιανουαρίου 2017

Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure [Microbiology]

Recoding viral genomes by numerous synonymous but suboptimal substitutions provides live attenuated vaccine candidates. These vaccine candidates should have a low risk of deattenuation because of the many changes involved. However, their genetic stability under selective pressure is largely unknown. We evaluated phenotypic reversion of deoptimized human respiratory syncytial virus...

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