Genetic analysis in post-mortem samples with micro-ischemic alterations

Sudden cardiac death (SCD) can result from several cardiovascular diseases and is one of the leading causes of death in the world [1]. SCD can occur at any age; overall, coronary artery disease and acute myocardial infarction (MI) are primarily responsible for SCD in people over 35 years old [2]. Cardiac arrest is the most common cause of death in patients who have suffered a previous MI, and the risk increases within the first month after MI [3]. The scar related to the MI provides the underlying substrate, and cardiac conduction abnormalities and repolarization deficiencies play a key role in the development of lethal arrhythmias and ventricular fibrillation (VF) after MI.

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