Τρίτη 17 Ιανουαρίου 2017

Diverse evolutionary patterns of pneumococcal antigens identified by pangenome-wide immunological screening [Microbiology]

Characterizing the immune response to pneumococcal proteins is critical in understanding this bacterium’s epidemiology and vaccinology. Probing a custom-designed proteome microarray with sera from 35 healthy US adults revealed a continuous distribution of IgG affinities for 2,190 potential antigens from the species-wide pangenome. Reproducibly elevated IgG binding was elicited by...

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