Coregulator-mediated control of skeletal muscle plasticity – a mini-review

Publication date: Available online 3 January 2017
Source:Biochimie
Author(s): Svenia Schnyder, Barbara Kupr, Christoph Handschin
Skeletal muscle plasticity is a complex process entailing massive transcriptional programs. These changes are mediated by the action of nuclear receptors and other transcription factors. In addition, coregulator proteins have emerged as important players in this process by linking transcription factors to the RNA polymerase II complex and inducing changes in the chromatic structure. An accumulating body of work highlights the pleiotropic functions of coregulator proteins in the control of tissue-specific and whole body metabolism. In skeletal muscle, several coregulators have been identified as potent regulators of metabolic and myofibrillar plasticity. In this mini-review, we will discuss the regulation, function and physiological significance of these coregulators in skeletal muscle biology.



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