Semi-quantifiable angiogenesis parameters in association with the malignant transformation of oral leukoplakia.

Semi-quantifiable angiogenesis parameters in association with the malignant transformation of oral leukoplakia.

J Oral Pathol Med. 2016 Dec 30;:

Authors: Thiem D, Schneider S, V NT, V Kumar V, Brieger J, Frerich B, Kämmerer PW

Abstract
BACKGROUND: Aim of the study was to assess the role of angiogenesis in the process of malignant transformation of clinical diagnosed oral leukoplakia (OL).
MATERIALS AND METHODS: 131 histological preparations (oral leukoplakia/hyperkeratosis without dysplasia (OL; n=49), oral leukoplakia/hyperkeratosis with mild dysplasia (OL-SIN1; n=33), with moderate dysplasia (OL-SIN2; n=13) and leukoplakia-derived oral squamous cell carcinoma (OL-OSCC; n=36)) were evaluated for microvessel density (MVD), vessel diameter as well as for vascular endothelial growth factor (VEGF-A) expression. Data were compared within the groups.
RESULTS: For MVD, there were significant differences between OL and OL-SIN 2/OL-OSCC (P < 0.05) and between OL-SIN 1 and OL-OSCC (P < 0.05). For OL-OSCC, vessel diameters were significantly increased compared to OL (P < 0.05). Expression of VEGF-A increased significantly gradually from OL-SIN 1 to OSCC (each P < 0.05). This was especially evident for lesions of the tongue when compared to the others.
CONCLUSION: Angiogenesis increases during the transition from OL through dysplasia to OL-OSCC. Especially in OL-OSCCs of the tongue, VEGF-A-expression may be used for estimation of malignant progression of OL. This article is protected by copyright. All rights reserved.

PMID: 28036153 [PubMed - as supplied by publisher]

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