Airway and Pulmonary β2-adrenergic Vasodilatory Function in Current-smokers and Never-smokers

Background

Cigarette smoking has been associated with diminished vasodilatory function in the airway circulation. It is possible that cigarette smoking similarly affects the pulmonary circulation before resting pulmonary circulatory abnormalities manifest.

Objectives

To compare in smokers and never-smokers the acute effect of inhaled albuterol on airway and pulmonary hemodynamic function, as an index of β2-adrenoceptor-mediated vasodilation.

Methods

In 30 adults, airway and pulmonary vascular function was assessed before and 15-min after albuterol inhalation (270 μg). From mean systemic arterial pressure (MAP), cardiac output, airway blood flow (Qaw), and mean pulmonary arterial pressure (MPAP), airway vascular resistance (AVR) and pulmonary vascular resistance (PVR) were derived.

Results

Albuterol induced a substantial drop in mean (± SE) PVR (-67.2% ± 5%), with no difference between groups. In contrast, the albuterol-induced decrease in AVR was significantly greater in never-smokers than smokers (-28.6% ± 3% vs. -3.1% ± 6%; p Conclusions

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