Screening of a novel-substituted furan compound for analgesic activity in mice

2016-09-17T00-38-45Z
Source: International Journal of Basic & Clinical Pharmacology
Nithya Karnam, Jayakumar J.K., Supriya, Revanaswamy.
Background: Pain is an unpleasant sensation and is the most primitive of all senses. It is a major symptom in many medical conditions and can significantly interfere with a person's quality of life and general functioning. Analgesics like opioids and NSAIDS are used to treat pain but due to their side effects on long term use it is necessary to develop a compound with reduced side effects. Hence the present study was focused on screening of novel compound of novel compound 2-(4-nitrophenylimino)-N-cyclohexyl-4,5 diphenylfuran-3- carboxamide (AMSM-2(a-k) for analgesic activity in mice. Methods: The analgesic activity of test compound AMSM-2(a-k) at different doses (5 mg/kg, 10 mg/kg and 20 mg/kg) was evaluated by using Eddys hot plate for determining central analgesic activity using morphine (5 mg/kg) as standard drug, acetic acid induced writhing test for peripheral analgesic activity and formalin induced writhing test to evaluate both central and peripheral analgesic activity using aspirin as standard drug (300 mg/kg). The percentages of inhibition of writhings were calculated for acetic acid and formalin induced pain model. The statistical analysis was done using one way ANOVA followed by Dunnetts test. All values with P


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