INVESTIGATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF BURDOCK THICK EXTRACTS ON THE MODEL OF BENIGN PROSTATIC HYPERPLASIA (BPHP) IN RATS

2016-09-28T01-17-06Z
Source: Journal of Molecular Pathophysiology
Shchokina Catherine, Ulanova Vera.
Introduction. Benign prostatic hyperplasia (BPHP) is one of the most common diseases in men middle-aged and elderly. In this regard, search and study of new effective and safe medicines with prostatoprotective effect is important and actual. Methods. BPHP model reproduced the intraperitoneal administration of sulpiride male rats, 40 mg / kg for 30 days. Thick Burdock extracts at a dose of 75 mg / kg and reference drug prostaplant forte, 35 mg / kg were administered intraperitoneally in a medical mode 31 to day 52 of the study. Results. The administration of thick extract of burdock roots contributed to the reliable normalization of acid phosphatase activity in serum of animals, as it is evidenced by the absence of significant differences of indicator of the treated animals from the same indicator in the groups of animals with intact control. The administration of thick extract of burdock roots contributed to a significant inhibition of LPO processes, normalization of reduced glutathione and diene conjugates in the serum levels of thiobarbituric acid active products and reduced glutathione in the homogenate of the prostate. The effect of the indicators mentioned above thick extract of burdock roots was not significantly inferior to the effect of the drug compared with Prostaplant Forte. Thick extract of burdock leaves inferior to thick extract of burdock roots and the reference drug by normalizing influence on the activity of acid phosphatase, the level of reduced glutathione and diene conjugates in blood serum of the experimental animals. Conclusions. The one of the most important components of the mechanism of the prostate protective action of burdock thick extracts in benign hyperplasia of the prostate gland are their anti-inflammatory and antioxidant action wich are not inferior to the reference drug Prostaplant Forte.


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