Antihypertensive and antiatherogenic effects of Tanopati a traditional recipe used for the treatment of high blood pressure

2016-09-23T23-25-50Z
Source: International Journal of Basic & Clinical Pharmacology
Amani Komenan Nazaire, Djyh Bernard Nazaire, Boga Gogo Lucien, Kouassi Konan, Severin Kouakou Konan, NGuessan Jean David.
Background: The objective of the present study was to investigate the possible effect of Tanopati on induced hypercholesterolemia in rats and hypertension in rabbits. Methods: Twenty wistar rats were divided into 4 groups each and then subjected to different treatments. Hypercholesterolemia was induced by induced dietary cholesterol; the rats are then treated with Tanopati and Questran®) Sixteen rabbits males, divided in four lots with four rabbits each, were used in this study. Hypertension was induced by adrenalin (1 mg/ml for 2 weeks intramuscularly) in the lots 2 to 4. After induction of hypertension in animals, they were treated with the extract of Tanopati. The cardiovascular parameters of rabbits (systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) was taken with an electric manometer. These three cardiovascular parameters were then compared to the witness group. Results: The treatment with the Tanopati and with Questran® significantly improved (p


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