Is there an association between study size and reporting of study quality in dermatological clinical trials? A meta-epidemiological review

Abstract

Clinicians engaged in evidence-based medicine often have to base treatment decisions on randomised clinical trials (RCTs) with small sizes.¹ The choice of sample size is influenced by a number of factors including power, magnitude of difference anticipated, alpha, study design and whether the objective of the trial is equivalence or superiority. Based on our experience of reviewing hundreds of dermatological clinical trials, we hypothesized that sample size could be a crude surrogate of study quality in that larger studies are of generally better quality than smaller ones.

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