Common-Lymphoid-Progenitor-Independent Pathways of Innate and T Lymphocyte Development

Publication date: Available online 7 April 2016
Source:Cell Reports
Author(s): Maryam Ghaedi, Catherine A. Steer, Itziar Martinez-Gonzalez, Timotheus Y.F. Halim, Ninan Abraham, Fumio Takei
All lymphocytes are thought to develop from common lymphoid progenitors (CLPs). However, lymphoid-primed multipotent progenitors (LMPPs) are more efficient than CLPs in differentiating into T cells and group 2 innate lymphoid cells (ILC2s). Here, we have divided LMPPs into CD127⁻ (LMPP−s) and CD127⁺ (LMPP+s) subsets and compared them with Ly6D⁻ and Ly6D⁺ CLPs. Adult LMPP+s differentiated into T cells and ILCs more rapidly and efficiently than other progenitors in transplantation assays. The development of T cells and ILC2s is highly active in the neonatal period. Neonatal CLPs are rare and, unlike prominent neonatal LMPP+s, do not efficiently differentiate into T cells and ILC2s. ILC2s generated in the neonatal period are long lived and persist in adult tissues. These results suggest that some ILCs and T cells may develop from LMPP+s via CLP-independent pathways.

Graphical abstract

Teaser

Ghaedi et al. report that individual lymphoid lineages can develop from multiple progenitors with varying probabilities. CD127⁺ LMPPs (LMPP+s) have a high probability of differentiating into the ILC and T cell lineages without differentiating into CLPs.


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