Παρασκευή 4 Μαρτίου 2016

Context-Dependent Development of Lymphoid Stroma from Adult CD34+ Adventitial Progenitors

Publication date: Available online 3 March 2016
Source:Cell Reports
Author(s): Katarzyna M. Sitnik, Kerstin Wendland, Holger Weishaupt, Heli Uronen-Hansson, Andrea J. White, Graham Anderson, Knut Kotarsky, William W. Agace
Despite the key role of primary and secondary lymphoid organ stroma in immunity, our understanding of the heterogeneity and ontogeny of these cells remains limited. Here, we identify a functionally distinct subset of BP3PDPN+PDGFRβ++CD34+ stromal adventitial cells in both lymph nodes (LNs) and thymus that is located within the vascular niche surrounding PDPNPDGFRβ+Esam-1+ITGA7+ pericytes. CD34+ adventitial cells developed in late embryonic thymus and in postnatal LNs and in the thymus originated, along with pericytes, from a common anlage-seeding progenitor population. Using lymphoid organ re-aggregate grafts, we demonstrate that adult CD34+ adventitial cells are capable of differentiating into multiple lymphoid stroma-like subsets including pericyte-, FRC-, MRC-, and FDC-like cells, the development of which was lymphoid environment-dependent. These findings extend the current understanding of lymphoid mesenchymal cell heterogeneity and highlight a role of the CD34+ adventitia as a potential ubiquitous source of lymphoid stromal precursors in postnatal tissues.

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Teaser

Sitnik et al. comparatively assess the stromal cell composition of the thymus and lymph nodes. The authors identify CD34+ adventitial cells as a conserved component of the thymic and lymph node vascular niche and demonstrate that this subset contains adult progenitors with lymphoid stroma-like subset potential in vivo.


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