Malignant uterine perivascular epithelioid cell tumor: histopathologic and immunohistochemical characterization of a rare tumor in a post-menopausal woman

xlomafota13 shared this article with you from Inoreader Malignant uterine perivascular epithelioid cell tumor: histopathologic and immunohistochemical characterization of a rare tumor in a post-menopausal woman Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Sep 15;14(9):993-999. eCollection 2021. ABSTRACT BACKGROUND: Perivascular epithelioid cell tumors (PEComas) are rare, mesenchymal neoplasms composed of epithelioid cells exhibiting myogenic and melanocytic differentiation. The uterus is an infrequent site of involvement. The most common histopathologic mimics include leiomyosarcoma, endometrial stromal sarcoma, undifferentiated uterine sarcoma, and malignant melanoma. Rendering an accurate histopathologic diagnosis is essential, owing to the prognostic and therapeutic implications. CASE: A 65-years-old post-menopausal woman presented with post-menopausal bleeding, abdominal pain, and heaviness for the last four months. Ultrasound abdomen revealed a large uterine mass replacing the endometrial cavity. She underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy. RESULT: Microscopically, a circumscribed tumor with tumor cells a rranged in sheets and interlacing fascicles, with interspersed fine capillary network, was seen. The individual tumor cells were epithelioid to spindle with moderate pleomorphism, round nuclei, vesicular chromatin, prominent macronucleoli, and moderate cytoplasm. Mitosis was 2-3/50 HPFs. On immunohistochemistry, tumor cells were positive for HMB-45, Melan-A, and smooth muscle actin and were negative for h-caldesmon, TFE3, S-100, CD10, and pan-cytokeratin. Based on the histopathologic and immunohistochemical features, a final diagnosis of malignant uterine PEComa was rendered. CONCLUSIONS: This index report describes the characteristic histopathologic and immunohistochemical features of malignant uterine PEComa and highlights the salient features that distinguish it from other commonly encountered histopathologic mimics. PMID:34646418 | PMC:PMC8493258 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The application of orthodontic bone stretching for correcting malpositioned dental implants

xlomafota13 shared this article with you from Inoreader The application of orthodontic bone stretching for correcting malpositioned dental implants Via Head & Face Medicine Dental implants are sometimes initially placed in a wrong position leading to esthetic damage, which is difficult to solve with prosthetics. Moreover, implants placed in the anterior sector, like ankylosed tee... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Disease-free time stratification in locally recurrent head and neck carcinoma after definitive radiotherapy or chemoradiotherapy

xlomafota13 shared this article with you from Inoreader Disease-free time stratification in locally recurrent head and neck carcinoma after definitive radiotherapy or chemoradiotherapy Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Oct 14. doi: 10.1007/s00405-021-07116-6. Online ahead of print. ABSTRACT PURPOSE: There is no standard definition of disease-free interval before local recurrence after treatment in head and neck carcinoma (HNSCC). We evaluated an easy-to-use stratification and its association with survival in a large cohort of patients. METHODS: We performed a retrospective cohort analysis of prognostic variables in 325 HNSCC patients with a local recurrence after definitive radiotherapy or concurrent chemoradiotherapy. Endpoints were overall survival (OS) and post-recurrence survival (PRS). RESULTS: Variables associated with the survival were the patient age (OS p < 0.0001, PRS p < 0.0001), the initial disease stage (OS p = 0.24, PRS p = 0.0358), localization (OS p = 0.012, PRS p = 0.0002), a complete initial response to treatment (OS p < 0.0001, PRS p = 0.019), synchronous regional or distant meta static disease (OS p = 0.0094, PRS p < 0.0001), a salvage surgery (OS p < 0.0001, PRS p < 0.0001) and time to recurrence (OS p = 0.0002, PRS p = 0.0029). Time to recurrence could be stratified between specific prognostic time categories that comprised disease persistence, early recurrence (< 12 months), standard recurrence (12 months-5 years) and late recurrence (> 5 years). CONCLUSION: In HNSCC patients, time to local recurrence is a prognostic variable that can be defined using an easy-to-use stratification. PMID:34648050 | DOI:10.1007/s00405-021-07116-6 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Voice Quality and Vocal Tract Discomfort Symptoms in Patients with COVID-19

xlomafota13 shared this article with you from Inoreader Voice Quality and Vocal Tract Discomfort Symptoms in Patients with COVID-19 Via Journal of Voice Dysphonia and laryngeal problems are some of the manifestations of the COVID-19 pandemic due to respiratory disease as a primary effect of COVID-19. The aim of the present study was to investigate voice quality and vocal tract discomfort symptoms in patients with COVID-19. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cerebrospinal Fluid Leaks Following Anterior Skull Base Trauma: A Systematic Review of the Literature

xlomafota13 shared this article with you from Inoreader Cerebrospinal Fluid Leaks Following Anterior Skull Base Trauma: A Systematic Review of the Literature Via leak of cerebrospinal fluid World Neurosurg. 2021 Oct 9:S1878-8750(21)01562-X. doi: 10.1016/j.wneu.2021.10.065. Online ahead of print. ABSTRACT BACKGROUND: Anterior skull base (ASB) fractures are reported in 4% of head injuries and represent 21% of all skull fractures. Cerebrospinal fluid (CSF) leaks may follow, severely exacerbating outcomes. We systematically reviewed the literature to analyze and compare the roles of endoscopic surgery, open surgery, and combined approaches in the management of CSF leak repair following post-traumatic ASB fractures. METHODS: PubMed, Web of Science, and Scopus databases were searched in accordance with the PRISMA guidelines. Studies reporting clinical data of patients with CSF leaks following ASB fracture were reviewed, focusing on management strategies and post-treatment outcomes. RESULTS: We included 29 articles comprising 888 patients. The average age at diagnosis was 34 years (range 18-91), with a male predominance (54 %) and a male/female ratio of 2.9:1 (647/241). Clinical data was available for 888 patients with CSF leaks post-ASB fracture, reporting a median follow-up time of 33.5 months (SD: ±29; range 0.5-330.0 months). Open surgical repair was the most common approach (67.9%), followed by endoscopic surgical repair (32.1%). The endoscopy cohort showed lower rates of complications (0.7% vs. 11.1%) and fistula recurrence (2.8% vs. 5.3%) compared to open surgery. CONCLUSION: ASB fractures are frequently treated as late surgery, 24 hours from injury or later, especially for endoscopic surgery. The endoscopic approach is overall preferred, mostly because of its safety and effectiveness, offering lower failure rates than open surgery. PMID:34637942 | DOI:10.1016/j.wneu.2021.10.065 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Trends in contrast media research the last 100 years

xlomafota13 shared this article with you from Inoreader Trends in contrast media research the last 100 years Via radioactive iodine Acta Radiol. 2021 Oct 12:2841851211051014. doi: 10.1177/02841851211051014. Online ahead of print. ABSTRACT This review focuses on the trends in contrast media (CM) research published in Acta Radiologica during the last 100 years, since the first edition in 1921. The main topics covered are the developments of iodine- and gadolinium-based CM. Other topics include manganese-based CM for magnetic resonance imaging (MRI) and barium for the investigation of the alimentary tract. From a histori c point of view, special CM for use in cholegraphy and myelography are addressed in the review. Today, these imaging procedures are obsolete due to the development of computed tomography, MRI, and ultrasound. The historical use of radioactive thorium-based CM for angiography is also addressed. Furthermore, publications on adverse reactions to CM are reviewed. PMID:34636678 | DOI:10.1177/02841851211051014 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Expanding indication of free hypothenar flap transfer: Sequential pedicled ulnar palm flap transfer to a relatively large hypothenar flap donor site

xlomafota13 shared this article with you from Inoreader Expanding indication of free hypothenar flap transfer: Sequential pedicled ulnar palm flap transfer to a relatively large hypothenar flap donor site Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Sep 20:S1748-6815(21)00408-3. doi: 10.1016/j.bjps.2021.08.021. Online ahead of print. ABSTRACT BACKGROUND: Free hypothenar flap (HTF) transfer allows sensible soft tissue reconstruction of the fingertip. However, HTF is basically indicated for a relatively small soft tissue defect, as width of an HTF is limited up to approximately 20 mm to allow primary donor site closure. Combined with sequential local flap to an HTF donor site, a larger HTF can be used without the contracture risk. The aim of this study was to evaluate feasibility of free HTF transfer and sequential ulnar palm flap (UPF) transfer (HTF-UPF) for relatively large fingertip reconstructions. METHODS: Medical charts of patients who underwent HTF-UPF for fingertip reconstruction were reviewed. An HTF was designed transversely proximal to the proximal palmar crease, and a slightly smaller hemi-spindle-shaped UPF was designed longitud inally on the mid-lateral aspect of the ulnar palm; the UPF was used to close the HTF donor site. Patient and flap characteristics, intra-operative findings, and postoperative results were evaluated. RESULTS: Twelve patients with average age of 42.7 years were included. HTF-UPF procedure was performed on 12 fingers. HTF's length/width ranged from 45/20 to 70/40 mm (average, 52.5/32.1 mm). UPF's length/width ranged from 40/20 to 55/30 mm (average, 46.7/24.2 mm). Time for sequential UPF transfer ranged from 3 to 9 min (average, 5.1 min). All HTFs and UPFs survived without flap necrosis or scar contracture. Postoperative sensation was comparable with the contralateral fingertip. CONCLUSIONS: HTF-UPF procedure allows relatively large fingertip reconstruction with a minimum risk of HTF donor site contracture. PMID:34642064 | DOI:10.1016/j.bjps.2021.08.021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.