Quality of nurse patient therapeutic communication and overall patient satisfaction during their hospitalization stay

2016-12-09T08-55-28Z
Source: International Journal of Medical Science and Public Health
Sandhya Negi, Harleen Kaur, Grace M Singh.
Background: Effective communication is very important aspect in a nursing career. When patient admitted in the ward then therapeutic nurse patient relationship developed and if person is not mentally disturbed so that is very important nurses will properly communicate or needs to show a greater amount of interest to the information-giving process and decision making regarding the care of the patient. Objectives: The main aim of the research is to find the quality of nurse patient therapeutic communication and overall patient satisfaction during their hospitalization stay. Material and Method: An exploratory descriptive design was followed. A total of 110 patients were recruited by convenient sampling technique. Self developed Likert scale is used to assess the quality of nurse patient therapeutic communication and patient satisfaction. Result: Finding suggests that the most (81.8%) of the patient agreed that nurse was helpful and should concern on them, and 81% of the patient agreed that privacy and confidentiality was maintained. Only a few patients (4.5%) agreed that nurses were prompt in decision-making regarding their care.


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Retrospective case control study on typhoid and non-typhoid small bowel perforation

2016-12-09T04-03-50Z
Source: International Journal of Research in Medical Sciences
Sandeep Mahapatra, Charan Panda.
Background: Out of several causes of small bowel perforations, Typhoid is the commonest cause in tropical countries claiming a higher morbidity and mortality profile. In Spite of conducting a good clinical examination and a battery of investigatory procedures, the etiology of perforation still remains obscure in a good number of cases. This retrospective case control study was conducted with an objective to evaluate the causes of small bowel perforation and to compare the surgical procedures and the outcomes in patients of typhoid and non-typhoid small bowel perforations. Methods: This study was based on hospital records for the last 3 years from April 2003 to April 2006. All the cases that were admitted with perforations had undergone a battery of tests to rule out the causes. 69 patients had one or the other test positive for typhoid (cases); the other causes of perforation were taken as control (n=43). Results: In typhoid perforations, although none of the operative procedures are clearly advantageous over the other, but anastomoses including the by-pass procedures are associated with more of complications wound dehiscence (p value 0.004), anastomotic leakage (p value 0.04), intra-abdominal collections (p value 0.009) with a longer hospital stay and hence to be avoided as practicable. Conclusions: Typhoid ileal perforation still has a poor prognosis with high morbidity and mortality. Late presentation, delayed surgery, multiple perforations, severe peritoneal contamination, and post-operative faecal fistula are factors that have an adverse effect on mortality. Most deaths occur during the early post-operative period, with survivors having a prolonged hospital stay.


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Alpha1-antitrypsin restores colonic epithelial permeability in irritable bowel syndrome with diarrhea

2016-12-08T17-06-24Z
Source: Journal of Molecular Pathophysiology
Julien Boyer, Marie-Hélène Vivinus-Nébot, Valérie Verhasselt, Thierry Piche, Meri K Tulic.



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Solving the puzzle: what is behind our forefathers’ anti-inflammatory remedies?

2016-12-08T15-46-06Z
Source: Journal of Intercultural Ethnopharmacology
Javier Rodriguez Villanueva, Jorge Martín Esteban, Laura Rodríguez Villanueva.
Inflammation is a ubiquitous host response in charge of restoring normal tissue structure and function but is a double-edged sword, as the uncontrolled or excessive process can lead to the injury of host cells, chronic inflammation, chronic diseases and also neoplastic transformation. Throughout history, a wide range of species have been claimed to have anti-inflammatory effects worldwide. Among them, Angelica sinensis, Tropaeolum majus, Castilleja tenuiflora, Biophytum umbraculum, to name just a few, have attracted the scientific and general public attention in the last years. Efforts have been made to assess their relevance through a scientific method. However, inflammation is a complex interdependent process, and phytomedicines are complex mixtures of compounds with multiple mechanisms of biological actions, which restricts systematic explanation. For this purpose, the omics techniques could prove extremely useful. They provide tools for interpreting and integrating results from both the classical medical tradition and modern science. As a result, the concept of network pharmacology applied to phytomedicines emerged. All of this is a step toward personalized therapy.


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The adjuvant use of calcium fructoborate and borax with etanercept in patients with rheumatoid arthritis: Pilot study

2016-12-08T15-46-06Z
Source: Journal of Intercultural Ethnopharmacology
Saad Abdulrahman Hussain, Sattar Jabir Abood, Faiq Isho Gorial.
Objective: The present study was designed to evaluate the effects calcium fructoborate (CFB) and sodium tetraborate (NTB) as supplements in Iraqi patients with active RA maintained on Etanercept. Materials and Methods: A double blind randomized placebo-controlled clinical trial with 60 days treatment period was carried out at Baghdad Teaching Hospital, Medical City, Baghdad, Iraq. Eighty RA patients were randomized into 3 groups to receive either 220 mg/day calcium fructoborate, 55 mg/day sodium tetraborate in capsule dosage form (equivalent to 6 mg elemental Boron), or placebo formula once daily. Only 72 patients completed the study. All patients were clinically evaluated utilizing DAS28-ESR, SDAI-CRP and CDAI scores at baseline and at the end of the study. Venous blood was obtained at baseline and after 60 days, and utilized for the measurement of erythrocyte sedimentation rate (ESR), hemoglobin (Hb), in addition to evaluation of C-reactive protein (hsCRP), TNF-α, interleukin-1α (IL-1α) and IL-6. Results: After 60 days, both types of boron significantly improve the clinical scores, in association with significant decrease in the serum levels of ESR, hsCRP, IL-1α, IL-6, and TNF-α with remarkable superiority for CFB over NTB, compared to baseline and placebo-treated group. Conclusion: The use of boron, as adjuvant with etanercept, have potentiated therapeutic outcomes in RA patients, and may be a new strategy to improve treatment and avoid the problems associated with biologics utilized in RA treatment.


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Primary Adrenal Lymphoma Infiltrating in to Pancreas: A Rare Cause of Adrenomegaly

2016-12-08T15-21-13Z
Source: Journal of Interdisciplinary Histopathology
Lovelesh Kumar Nigam, Kamal V Kanodia, Aruna V Vanikar, Rashmi D Patel, Kamlesh S Suthar, Syed J Rizvi.
Primary adrenal lymphoma is a rare entity and may be suspected in patients having bilateral adrenal masses, with/without lymphadenopathy, and with/without adrenal insufficiency. We report a rare case of a 45-year-old man who presented with pain in the abdomen, with no signs of adrenal insufficiency and bilateral adrenal masses on imaging. Light microscopy findings with immunohistochemistry and flow cytometry confirmed the diagnosis of diffuse large B-cell lymphoma. The patient was offered cyclophosphamide, adriamycin, vincristine, and prednisolone chemotherapy regimen and doing well till the last follow-up.


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The Significance of BerEp4 and Cytokeratin 19 Expressions in Epithelial Tumors of Kidney and Renal Pelvis

2016-12-08T15-21-13Z
Source: Journal of Interdisciplinary Histopathology
Ayhan Ozcan, Ibrahim Yavan, Melih Kilinc, Sami Uguz, Sukru Ozaydin.
Objective: The differential diagnosis in the epithelial tumors of kidney and renal pelvis can be problematic due to their overlapping morphologic features. This is much more complicated in some conditions, such as renal oncocytoma (RO) vs chromophobe renal cell carcinoma (ChRCC) and renal cell carcinoma (RCC) vs urothelial carcinoma of renal pelvis (UC-RP). The purpose of this study was to assess potential contributions of BerEP4 and cytokeratin 19 (CK19) expressions in the differential diagnosis of these challenging cases. Methods: A total 57 cases consisted of 11 chromophobe (ChRCC), 18 clear cell (CCRCC), 12 papillary (PRCC), and 2 unclassified RCCs, 1 multilocular cystic renal cell neoplasm (MCRCN) with low malignant potential, 7 UC-RP, and 6 renal oncocytomas (RO) were stained against BerEp4 and CK19 antibodies using automated immunostainer. Results: All ROs demonstrated membranous BerEP4 expression, but no CK19 expression. Unlike ROs, most ChRCCs exhibited diffuse and strong CK19 expression, but no or focal and weak BerEP4 expression. This distinctive opposite expression pattern was highlighted in hybrid oncocytic chromophobe tumor (HOCT). CCRCCs showed highly variable expression patterns for both markers. PRCC type 1 tumors demonstrated diffuse and strong BerEp4 and CK19 expressions. PRCC type 2 exhibited BerEP4 and CK19 expressions, but their expressions were focal and weaker than for PRCC type 1. MCRCN demonstrated diffuse and strong BerEP4 expression, but no expression for CK19 unlike cystic CCRCC, which is strongly positive for both markers. Epithelioid cells in unclassified RCC showed strong CK19 and weak BerEP4 expression, whereas spindle cells in the tumor did not express CK19 and BerEp4 or exhibited scattered and weak expressions. UC-RP showed diffuse and strong CK19 expression, but no or scattered BerEP4expression was seen in the tumor. We also evaluated CK19 and BerEP4 expression in non-neoplastic adjacent kidney and renal pelvis. Conclusion: This study revealed that 1) BerEP4 and CK19 exhibit variable and distinctive immunoprofiles in epithelial tumors of kidney and renal pelvis, 2) an immunoprofile of BerEP4 (+)/CK19 (-) favors RO in contrast to an opposite profile for ChRCC, 3) The heterogeneous expressions of BerEP4 and CK19 in low grade RCC with eosinophilic cytoplasm favors HOCT, 4) PRCC type 1 strongly express both biomarkers, and 5) although RCC subtypes express CK19 in a variable proportion and intensity, diffuse and strong CK19 expression favors UC-RP.


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