Oral squamous cell carcinoma outcome in adolescent/young adult: Systematic review and meta‐analysis

xlomafota13 shared this article with you from Inoreader Oral squamous cell carcinoma outcome in adolescent/young adult: Systematic review and meta‐analysis Via Head & Neck Abstract To perform a systematic review focusing on the prognosis of oral cavity squamous cell carcinoma (OSCC) in young patients (≤40 years old) compared to older (>40 years old). Four databases were used in our search strategy. First, all titles were systematically organized using the Covidence platform online. In the second phase, 118 full texts of potentially eligible studies were analyzed by reviewers independently and in pairs. Twelve studies were considered eligible for data extraction. The relapse was higher in the young than in controls (pooled relative risk (RR) = 1.31; 95% CI [1.10–1.56]). The 5-year disease-free survival (DFS) was worse in young group (pooled hazard ratio (HR) = 0.73; 95% CI [0.63–0.85]) but the 5-year overall survival (OS) estimate was similar between the groups (pooled HR = 0.84; 95% CI [0.70–1.00]). While the 5-year OS was similar between groups, the number of relapses and 5-year DFS were worse in patients with OS CC ≤40 years old. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Assessment of swallow function pre and post‐endoscopic CO2 laser medial arytenoidectomy: a case series

xlomafota13 shared this article with you from Inoreader Assessment of swallow function pre and post‐endoscopic CO2 laser medial arytenoidectomy: a case series Via Clinical Otolaryngology Abstract Endoscopic CO2 laser medial arytenoidectomy is performed for glottic stenosis however post-operative aspiration remains a risk Pre-operative and post-operative objective and subjective assessments of swallow function were evaluated There was no statistically significant difference when comparing pre- and post-operative penetration-aspiration scores or subjective swallow function If baseline swallow is impaired, this should not preclude the patient from arytenoidectomy; baseline FEES is essential to aid surgical planning and inform patient consent 'Staged arytenoidectomy' should be performed as a swallow-preserving procedure View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Value of Diversity, Equity, and Inclusion in Otolaryngology

xlomafota13 shared this article with you from Inoreader The Value of Diversity, Equity, and Inclusion in Otolaryngology Via Otolaryngologic Clinics of North America Diversity impacts performance of our teams, fosters innovation, and improves outcomes of our patients in otolaryngology head and neck surgery. In addition to the moral imperative, increasing the otolaryngology diversity workforce will decrease health care disparities while equity and justice can increase the culture humility to take care of an increasingly diverse patient population. To move toward justice, otolaryngology departments need to end biases in faculty hiring, development, research evaluations, and publication practices. The more intentional our efforts, the more benefit to our patients, providers, staff, learners, and society. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

“Business” Is not a Four-Letter Word

xlomafota13 shared this article with you from Inoreader "Business" Is not a Four-Letter Word Via Otolaryngologic Clinics of North America Remember back to when you decided you wanted to be a physician? You made the conscious decision to study instead of going out, to spend your weekends and evenings buried in books and memorization, maybe even foregoing that really interesting humanities course because you had to "ace" organic chemistry. You did this because you wanted to be a doctor to help people and make a difference in this world, and that's what you told your medical school interviewers. Me, too. Not one of us said, "I want to be a doctor and make sure I run my business profitably so that I can pay my staff and myself fairly and stay in business to continue to help more patients and provide for my family and retire comfortably." Likewise, our curricula in medical school were rich in basic and clinical sciences, and more recently in ethics and communication, but, all along training, information continues to be sparse regarding business basics, employment and insurance negotiations, the intricacies o f human resource management, billing, coding and getting paid, what to do in case you are sued, and how to plan for your and your family's financial future. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The log odds of positive neck lymph nodes is a superior lymph node predictor for overall survival in head and neck cancer: a population-based analysis in Germany

xlomafota13 shared this article with you from Inoreader The log odds of positive neck lymph nodes is a superior lymph node predictor for overall survival in head and neck cancer: a population-based analysis in Germany Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Nov 22. doi: 10.1007/s00405-021-07176-8. Online ahead of print. ABSTRACT BACKGROUND: This population-based study investigated the influence of different lymph node (LN) classifications on overall survival (OS) in head and neck cancer (HNC). METHODS: 401 patients (median age: 57 years; 47% stage IV) of the Thuringian cancer registries with diagnosis of a primary HNC receiving a neck dissection (ND) in 2009 and 2010 were included. OS was assessed in relation to total number of LN removed, number of positive LN, LN ratio, and log odds of positive LN (LODDS). RESULTS: Mean number of LODDS was 0-0.96 ± 0.57. When limiting the multivariate analysis to TNM stage, only the UICC staging (stage IV: HR 9.218; 95% CI 2.721-31.224; p < 0.001) and LODDS > - 1.0 (HR 2.120; 95% CI 1.129-3.982; p = 0.019) were independently associated with lower OS. CONCLUSION: LODDS was an independent and superi or predictor for OS in HNC in a population-based setting with representative real-life data. PMID:34807283 | DOI:10.1007/s00405-021-07176-8 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A multicentre retrospective cohort study on COVID-19-related physical interventions and adult hospital admissions for ENT infections

xlomafota13 shared this article with you from Inoreader A multicentre retrospective cohort study on COVID-19-related physical interventions and adult hospital admissions for ENT infections Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Nov 22. doi: 10.1007/s00405-021-07180-y. Online ahead of print. ABSTRACT PURPOSE: To report changes in adult hospital admission rates for acute ENT infections following the introduction of COVID-19-related physical interventions such as hand washing, use of face masks and social distancing of 2-m in the United Kingdom. METHODS: Retrospective cohort study comparing adult admissions with acute tonsillitis, peritonsillar abscess, epiglottitis, glandular fever, peri-orbital cellulitis, acute otitis media, acute mastoiditis, retropharyngeal abscess and parapharyngeal abscess in the 1-year period after the introduction of COVID-related physical interventions (2020-2021) with a 1-year period before this (2019-2020) in three UK secondary care ENT departments. RESULTS: In total, there were significantly fewer admissions for ENT infections (n = 1073, 57.56%, p < 0.001; RR 2.36, 95% CI [2.17, 2.56]) in the 2020-2021 period than in the 2019-2020 period. There were significant reductions in admissions for tonsillitis (64.4%; p < 0.001), peritonsillar abscess (60.68%; p < 0.001), epiglottitis (66.67%; p < 0.001), glandular fever (38.79%; p = 0.001), acute otitis media (26.85%; p = 0.01) and retropharyngeal and/or parapharyngeal abscesses (45.45%; p = 0.04). CONCLUSION: Our study demonstrates a sizeable reduction in adult admissions for ENT infections since the introduction of COVID-19-related physical interventions. There is evidence to support the use of physical interventions in the prevention of viral transmission of respiratory disease. Preventing ENT infections requiring admission through simple physical interventions could be of great benefit to the quality of life of patients and economical benefit to healthcare systems. PMID:34807284 | DOI:10.1007/s00405-021-07180-y View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Gene expression profiling of laminin α3 blocked keratinocytes reveals an immune‐independent mechanism of blistering

xlomafota13 shared this article with you from Inoreader Gene expression profiling of laminin α3 blocked keratinocytes reveals an immune‐independent mechanism of blistering Via Experimental Dermatology Abstract Laminin-332 pemphigoid is a rare and chronic autoimmune blistering disease which results in subepidermal blisters and erosive lesions predominantly localized to mucous membranes. As histologic inflammation is variable, and non-complement fixing IgG antibodies against laminin-332 are the predominant class of autoantibodies deposited at the epidermal basement membrane zone, we hypothesized that complement-independent pro-inflammatory and blistering pathways existed similarly to that previously shown in BP. As autoantibodies to laminin α3 are most prevalent, we studied the major cellular response to blockade of laminin α3 using a well characterized monoclonal antibody (P3H9-2). RNA-seq revealed upregulation of numerous desmosomal genes (DSG1, DSG3, DSC1, DSC3, DSP) as well as KRT1 and KRT10. Additionally, P3H9-2 treated cells demonstrated downregulation of most hemidesmosomal genes. A pro-inflammatory response was not appreciated. Using pharmacological inhibito rs, we identified both protein kinase C and NOTCH as key regulators of P3H9-2 induced differentiation. We lastly utilized 3D human skin equivalents to determine whether blockade of laminin α3 would lead to delayed blistering, consistent with keratinocyte differentiation. Significant blistering was noted after 72 hours of treatment, with only minimal separation at 24 hours. In summary, blockade of laminin α3 alters keratinocyte differentiation, representing a potential complement-independent mechanism of blistering. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.