Πέμπτη 26 Αυγούστου 2021

Evaluation of the Neuroanatomical Basis of Olfactory Dysfunction

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This cross-sectional study evaluates the role of the components of the olfactory pathway structures in impaired olfactory function.
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Maternal Thyroid Hormone Programs Cardiovascular Functions in the Offspring

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Thyroid, Ahead of Print.
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Predictive Value of Serum Thyroglobulin for Structural Recurrence Following Lobectomy for Papillary Thyroid Carcinoma

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Thyroid, Ahead of Print.
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Thyroglossal Duct Cyst Located in the Thyroid Gland Misdiagnosed With Thyroid Carcinoma: A Case Report and Literature Review

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Ear Nose Throat J. 2021 Aug 26:1455613211040583. doi: 10.1177/01455613211040583. Online ahead of print.

ABSTRACT

The clinicopathologic features of thyroglossal duct cyst when it develops ectopically in the thyroid gland remain unclear because of its rarity, which makes diagnosis difficult. Clinical diagnosis and treatment should not disregard the possibility of thyroglossal cysts located in the thyroid gland. We here report the current case to prepare others and provide data for the diagnosis and treatment of this kind of disease.

PMID:34433310 | DOI:10.1177/014556132110 40583

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High-grade salivary gland cancer: is surgery followed by radiotherapy an adequate treatment to reach tumor control? Results from a tertiary referral centre focussing on incidence and management of distant metastases

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Eur Arch Otorhinolaryngol. 2021 Aug 26. doi: 10.1007/s00405-021-07024-9. Online ahead of print.

ABSTRACT

PURPOSE: Salivary Gland cancer (SGC) is a rare and heterogenous group of tumors. Standard therapeutic options achieve high local but poor distant control rates, especially in high-grade SGC. The aim of this monocentric study was to evaluate patterns of recurrence and its treatment options (local ablative vs. systemic) in a homogenously treated patient population with high-grade SGC after surgery and radio(chemo)therapy.

METHODS: Monocentric, retrospective study of patients with newly diagnosed high-grade salivary gland cancer. We retrospectively reviewed clinical reports from 69 patients with high-grade salivary gland cancer in a single-center audit. Survival rates were calculated using the Kaplan-Meier method and prognostic variables were analyzed (univariate analysis: log-rank test; multivariate analysis: Cox regression anal ysis).

RESULTS: The median time of follow-up was 31 months. After 5 years, the cumulative overall survival was 65.2%, cumulative incidence of local recurrence was 7.2%, whereas the cumulative incidence of distant metastases was 43.5% after 5 years. 30 of 69 patients developed distant metastases during the time of follow-up, especially patients with adenoid cystic carcinoma, salivary duct carcinoma, adenocarcinoma NOS and acinic cell carcinoma with high-grade transformation. The most common type of therapy therefore was chemotherapy (50%). 85.7% of patients with local ablative therapy of distant metastases show disease progression during follow-up afterwards.

CONCLUSION: With surgery and radio-chemotherapy, a high rate of loco-regional control is reached, but over 40% of patients develop distant metastases in the further follow-up which usually present a diffuse pattern involving in a diffuse metastases. Therefore, in the future, intensified interdisciplinary combination therapies even in the first-line treatment in certain subtypes of high-grade SGC should be investigated.

PMID:34436631 | DOI:10.1007/s00405-021-07024-9

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Τρίτη 24 Αυγούστου 2021

Voice Outcomes Following Colon Interposition

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Ear Nose Throat J. 2021 Aug 24:1455613211041786. doi: 10.1177/01455613211041786. Online ahead of print.

ABSTRACT

SIGNIFICANCE STATEMENT: This case highlights the consequences of colon interposition on phonation and swallowing. Findings in this patient included laryngopharyngeal reflux, vocal fold paralysis, poor esophageal peristalsis, failed bolus transfers, and others. The mechanical and functional differences between the colon and the esophagus can impact bolus transfer, reflux, and phonation. Further research is required to identify the mechanisms by which colon interposition can impact voice and swallowing.

PMID:34427138 | DOI:10.1177/01455613211041786

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Clinical Approaches to External Auditory Canal Hemangiomas: A Systematic Review

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Ear Nose Throat J. 2021 Aug 24:1455613211042449. doi: 10.1177/01455613211042449. Online ahead of print.

ABSTRACT

OBJECTIVES: Hemangioma is a common soft tissue tumor that can be categorized mainly into cavernous, capillary, and venous subtypes. It usually develops in the head and neck and rarely in the external auditory canal (EAC).

METHODS: A systematic review of patients with capillary hemangioma of the EAC was performed. A computerized systematic search was conducte d in PubMed, Scopus, and Web of Science to extract relevant studies for a qualitative review.

RESULTS: A total of 38 patients were included in the systematic review, and half of them were men. Hearing loss was the most common presenting feature (n = 19; 50%), followed by aural fullness (n = 15; 39.4%). Cavernous hemangioma was the predominant type (n = 22, 57.8%). Endaural and transcanal surgical approaches were the most frequent, with 10 (26.3%) and 9 (23.6%) cases, respectively. Most of the patients (n = 31, 81.5%) had no recurrence.

CONCLUSIONS: Hemangioma of the EAC may not be uncommon, as health care professionals may expect. Hearing loss, aural fullness, and tinnitus are possible symptoms, but many patients remain asymptomatic. Surgical excision is the main effective management option, and complete resolution is the most prevalent outcome. Computed tomography assists in the diagnosis, but histopathological examination after resection is mandatory for the definitive diagnosis.

PMID:34427123 | DOI:10.1177/01455613211042449

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