Seltener Tumor im Oberlid

xlomafota13 shared this article with you from Inoreader Seltener Tumor im Oberlid Via Laryngo-Rhino-Otologie Laryngorhinootologie DOI: 10.1055/a-1475-5121 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Therapie von Sprachentwicklungsstörungen: Eine Leitlinie ist längst überfällig

xlomafota13 shared this article with you from Inoreader Therapie von Sprachentwicklungsstörungen: Eine Leitlinie ist längst überfällig Via Laryngo-Rhino-Otologie Laryngorhinootologie DOI: 10.1055/a-1408-7599 Für die Therapie von Sprachentwicklungsstörungen (SES) ist bislang weitgehend unklar, wie die Evidenz aus individueller therapeutischer Expertise in das klinisch-praktische Vorgehen integriert wird. Die Entwicklung einer Leitlinie zur Therapie von SES, insbesondere für Kindergarten- und Vorschulkinder, ist daher aus 2 Gründen längst überfällig und zugleich eine besondere Herausforderung: (1) SES, die nicht im Zusammenhang mit einer Komorbidität stehen, werden mit verschiedenen Termini belegt und (2) bilden alle SES eine Schnittstelle medizinischer, psychologischer, pädagogischer, linguistischer und sprachtherapeutischer Fachdisziplinen. Die Deutsche Gesellschaft für Phoniatr ie und Pädaudiologie hat nun eine „Interdisziplinäre (S3-) Leitlinie zur Therapie von Sprachentwicklungsstörungen" (Register-Nr. 049–015) bei der Arbeitsgemeinschaft Wissenschaftlicher Medizinischer Fachgesellschaften AWMF e. V. angemeldet. Damit soll die Lücke zwischen sprachtherapeutischer Praxis und Forschungsevidenz geschlossen werden, um für den individuellen Behandlungsfall eine möglichst optimale Therapieempfehlung bzw. Therapieentscheidung treffen zu können – basierend auf dem besten wissenschaftlich verfügbaren Fachwissen. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of conte nts  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

β-Ecdysone attenuates cartilage damage in a mouse model of collagenase-induced osteoarthritis via mediating FOXO1/ADAMTS-4/5 signaling axis

xlomafota13 shared this article with you from Inoreader β-Ecdysone attenuates cartilage damage in a mouse model of collagenase-induced osteoarthritis via mediating FOXO1/ADAMTS-4/5 signaling axis Via Cellular and Molecular Biology Histol Histopathol. 2021 Apr 20:18341. doi: 10.14670/HH-18-341. Online ahead of print. ABSTRACT BACKGROUND: β-Ecdysone has been reported to perform a protective effect to prevent interleukin 1β (IL-1β)-induced apoptosis and inflammatory response in chondrocytes. In our study, the chondroprotective effects of β-Ecdysone were explored in a mouse model of collagenase-induced osteoarthritis (OA). METHODS: Injection of collagenase in the left knee was implemented to establish a mouse model of OA. The histomorphological analysis was detected using safranine O staining. Serum pro-inflammatory cytokines were measured by ELISA assays. Protein expression in the femur and chondrocytes was analyzed using western blot. Chondrocyte apoptosis was evaluated by terminal-deoxynucleoitidyl transferase mediated nick end labeling (TUNEL) staining. RESULTS: Treatment of OA mice with β-Ecdysone supplementation significantly inhibited the pro duction of pro-inflammatory cytokines. Histologic examination exhibited that the degradation of proteoglycans and the loss of trabecular bone were observed in collagenase-injected mice. However, OA-like changes were attenuated by β-Ecdysone administration in collagenase-injected mice. Both in vivo and in vitro models, nuclear forkhead box O1 (FOXO1) protein expression was significantly reduced in the femur of collagenase-treated mice and IL-1β-stimulated chondrocytes. However, β-Ecdysone treatment was able to rescue FOXO1 protein expression in the nucleus to inhibit the transcription and translation of a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (ADAMTS-4) and ADAMTS-5. CONCLUSION: The findings suggested that β-Ecdysone functioned as a FOXO1 activator to protect collagenase-induced cartilage damage. FOXO1 might be a potential molecular target of β-Ecdysone for the effective prevention and treatment of OA. PMID:33876419 | DOI:10.14670/HH-18-341 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Prognostic Factors for the Outcome of Salivary Gland Holmium: YAG Laser Intraductal Lithotripsy

xlomafota13 shared this article with you from Inoreader Prognostic Factors for the Outcome of Salivary Gland Holmium: YAG Laser Intraductal Lithotripsy Via ear nose throat Ear Nose Throat J. 2021 Apr 20:1455613211010075. doi: 10.1177/01455613211010075. Online ahead of print. ABSTRACT OBJECTIVES: Holmium: YAG laser has gained its popularity throughout the years and is used to treat sialolithiasis, which helps to overcome the limitations of traditional sialendoscopic lithotripsy for larger-sized salivary stones. However, little information is available regarding factors predicting the success rate of Holmium: YAG laser intraductal lithotripsy. T he purpose of this study is to investigate the factors affecting the success rates of Holmium: YAG laser lithotripsy for salivary stones treatment in a tertiary care hospital. METHODS: A retrospective study conducted in patients receiving sialolithiasis surgery under sialendoscopy from May 2013 to March 2015 at Mackay Memorial Hospital, Taiwan. Data on various factors, including patients' age, gender, glands, size of largest stone, multiple stones (≥2 stones), location of the stone (distal duct, middle duct, proximal duct, and hilum), and operative time. The success of the surgery defined as patients without any complaints such as swelling or tenderness. Logistic regression and Fisher exact tests were employed to examine these factors on the success rate. RESULTS: Fifty-four patients who received sialendoscopy surgery with a mean age of 35.74 years old recruited. Logistic regression identified the operation time exceeding 210 minutes showed 23.497 folds higher odd rati o of having a result of operation failure (P < .05). CONCLUSION: The prolonged operation time is the sole independent factor affecting the successful outcome for salivary gland intraductal laser lithotripsy. We recommend operative time be no more than 210 minutes to increase the success rate in salivary gland Holmium: YAG laser intraductal lithotripsy. PMID:33877921 | DOI:10.1177/01455613211010075 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Craniofrontonasal dysplasia: hypertelorism correction in late presenting patients

xlomafota13 shared this article with you from Inoreader Craniofrontonasal dysplasia: hypertelorism correction in late presenting patients Via leak of cerebrospinal fluid Childs Nerv Syst. 2021 Apr 16. doi: 10.1007/s00381-021-05134-7. Online ahead of print. ABSTRACT BACKGROUND: Craniofrontonasal dysplasia (CFND) is a rare congenital craniofacial syndrome characterized by single suture synostosis, hypertelorism, other clinical facial features, and abnormalities in the upper extremities. There are only a few studies in the applicable literature that address hypertelorism management for CFND patients and outcomes and complication rates. METHODS: A retrospective study was performed on consecutive late presenting CFND patients referred to our hospital with substantially completed craniofacial skeleton growth, who underwent hypertelorism correction between 2007 and 2019 following intracranial pressure screening, and who received at least 1 year of follow-up care. None of the patients in this study underwent prior craniofacial surgery. Only those patients with a confirmed mutation of the EFNB1 gene were include d in this study. All patients in this study underwent hypertelorism correction by facial bipartition or box osteotomy. RESULTS: A total of ten late presenting CFND patients (all female) were treated at our hospital during the study period. None of the patients presented signs of elevated intracranial pressure. The average patient age at hypertelorism correction was 13.4 ± 7.68 years of age. Major complications, defined as complications requiring a return to the operating room, were limited to infection of the frontal bone, which required partial bone removal, and cerebrospinal fluid (CSF) leak, which was completely resolved by insertion of a lumbar shunt for a 7-day period. CONCLUSION: The absence of elevated intracranial pressure enables hypertelorism correction in late presenting CFND patients via facial bipartition or box osteotomy without the need for additional operations that provide for cranial expansion. PMID:33864106 | DOI:10.1007/s00381-021-05134-7 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nipple Engineering: Maintaining Nipple Geometry with Externally Scaffolded Processed Autologous Costal Cartilage

xlomafota13 shared this article with you from Inoreader Nipple Engineering: Maintaining Nipple Geometry with Externally Scaffolded Processed Autologous Costal Cartilage Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Mar 24:S1748-6815(21)00099-1. doi: 10.1016/j.bjps.2021.03.010. Online ahead of print. ABSTRACT INTRODUCTION: Nipple reconstruction is the essential last step of breast reconstruction after total mastectomy, resulting in improved general and aesthetic satisfaction. However, most techniques are limited by secondary scar contracture and loss of neo-nipple projection leading to patient dissatisfaction. Approximately, 16,000 patients undergo autologous flap breast reconstruction annually, during which the excised costal cartilage (CC) is discarded. We propose utilizing processed CC placed within biocompatible 3D-printed external scaffolds to generate tissue cylinders that mimic the shape, size and biomechanical properties of native human nipple tissue while mitigating contracture and projection loss. METHODS: External scaffolds were designed and then 3D-printed using polylactic acid (PLA). Patient-d erived CC was processed by mincing or zesting, then packed into the scaffolds, implanted into nude rats and explanted after 3 months for volumetric, histologic and biomechanical analyses. Similar analyses were performed on native human nipple tissue and unprocessed CC. RESULTS: After 3 months in vivo, gross analysis demonstrated significantly greater preservation of contour, projection and volume of the scaffolded nipples. Mechanical analysis demonstrated that processing of the cartilage resulted in implant equilibrium modulus values closer to that of the human nipple. Histologic analysis showed the presence of healthy and viable cartilage after 3 months in vivo, invested with fibrovascular tissue. CONCLUSIONS: Autologous CC can be processed intraoperatively and placed within biocompatible external scaffolds to mimic the shape and biomechanical properties of the native human nipple. This allows for custom design and fabrication of individualized engineered autologous imp lants tailored to patient desire, without the loss of projection seen with traditional approaches. PMID:33863678 | DOI:10.1016/j.bjps.2021.03.010 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effect of Electrode Configuration and Impulse Strength on Airway Patency in Neurostimulation for Obstructive Sleep Apnea

xlomafota13 shared this article with you from Inoreader Effect of Electrode Configuration and Impulse Strength on Airway Patency in Neurostimulation for Obstructive Sleep Apnea Via The Laryngoscope Objectives/Hypothesis Hypoglossal nerve stimulation (HNS) has gained increasing interest for the treatment of patients with obstructive sleep apnea (OSA). Drug‐induced sleep endoscopy (DISE) can both exclude improper airway collapse patterns and visualize airway changes under stimulation. Stimulation outcome effects depend on the impulse voltage and electric field resulting from the electrode configuration of the implanted device. The effects of various combinations of voltage and electric field on DISE airway patterns in contrast to awake endoscopy are unknown. Study Design Cohort study. Methods During therapy adjustment about 6 months after implantation, patients underwent a DISE and awake endoscopy with 100% and 125% of functional voltage in three typical electrode configurations (+ – +, o – o, − – −). All videos were analyzed by two separate persons for the opening of the airway at velum, tongue base, and epiglottis level. Results Thirty patients showed typical demographic data. The opening effects were visible in all patients, but there were changes between different electrode configurations. Several demographic or therapeutic aspects such as obesity, OSA severity, or prior soft palate surgery were associated with changes arising from different electrode configurations, but none resulted in a consistently better airway opening. Conclusions In patients with poor results during the therapy adjustment, electric configuration changes can improve airway patency—an independent variable from increasing voltage. As these effects can only be seen in awake endoscopy or DISE, both endoscopies with live stimulation may be considered in cases with insufficient improvement in apnea–hypopnea index after initiation of HNS therapy. Level of Evidence Prospective case series; level 4. Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.