Simultaneous Determination and Stability Studies on Diminazene Diaceturate and Phenazone Using Developed Derivative Spectrophotometric Method

This work presents UV first derivative spectrophotometry as a precise, accurate, and feasible method for simultaneous determination of diminazene diaceturate and phenazone in bulk and dosage forms. The absorbance values of diminazene diaceturate and phenazone aqueous mixture were obtained at 398 nm and 273 nm, respectively. The developed method was proved to be linear over the concentration ranges (2–10) μg/mL and (2.496–12.48) μg/mL for diminazene diaceturate and phenazone, respectively, with good correlation coefficients (not less than 0.997). The detection and quantitation limits were found to be (LOD = 0.63 and 0.48 μg/mL; LOQ = 1.92 and 1.47 μg/mL, resp.). The developed method was employed for stability studies of both drugs under different stress conditions. Diminazene diaceturate was prone to degrade at acidic pH via first-order kinetics. The degradation process was found to be temperature dependent with an activation energy of 7.48 kcal/mole. Photo-stability was also investigated for this drug.

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Parallel Evolutionary Peer-to-Peer Networking in Realistic Environments

In the present paper we first conduct simulations of the parallel evolutionary peer-to-peer (P2P) networking technique (referred to as P-EP2P) that we previously proposed using models of realistic environments to examine if P-EP2P is practical. Environments are here represented by what users have and want in the network, and P-EP2P adapts the P2P network topologies to the present environment in an evolutionary manner. The simulation results show that P-EP2P is hard to adapt the network topologies to some realistic environments. Then, based on the discussions of the results, we propose a strategy for better adaptability of P-EP2P to the realistic environments. The strategy first judges if evolutionary adaptation of the network topologies is likely to occur in the present environment, and if it judges so, it actually tries to achieve evolutionary adaptation of the network topologies. Otherwise, it brings random change to the network topologies. The simulation results indicate that P-EP2P with the proposed strategy can better adapt the network topologies to the realistic environments. The main contribution of the study is to present such a promising way to realize an evolvable network in which the evolution direction is given by users.

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Security Analysis of a Certificateless Signature from Lattices

Tian and Huang proposed a lattice-based CLS scheme based on the hardness of the SIS problem and proved, in the random oracle model, that the scheme is existentially unforgeable against strong adversaries. Their security proof uses the general forking lemma under the assumption that the underlying hash function is a random oracle. We show that the hash function in the scheme is neither one-way nor collision-resistant in the view of a strong Type 1 adversary. We point out flaws in the security arguments and present attack algorithms that are successful in the strong Type 1 adversarial model using the weak properties of the hash function.

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Internet of Things: Architectures, Protocols, and Applications

The Internet of Things (IoT) is defined as a paradigm in which objects equipped with sensors, actuators, and processors communicate with each other to serve a meaningful purpose. In this paper, we survey state-of-the-art methods, protocols, and applications in this new emerging area. This survey paper proposes a novel taxonomy for IoT technologies, highlights some of the most important technologies, and profiles some applications that have the potential to make a striking difference in human life, especially for the differently abled and the elderly. As compared to similar survey papers in the area, this paper is far more comprehensive in its coverage and exhaustively covers most major technologies spanning from sensors to applications.

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Decreased Tissue COX5B Expression and Mitochondrial Dysfunction during Sepsis-Induced Kidney Injury in Rats

Background. Sepsis is defined as a life-threatening organ dysfunction due to a dysregulated host response to infection. Sepsis is the dominant cause of acute kidney injury (AKI), accounting for nearly 50% of episodes of acute renal failure. Signaling cascades and pathways within the kidney are largely unknown and analysis of these molecular mechanisms may enhance knowledge on pathophysiology and possible therapeutic options. Material and Methods. 26 male Wistar rats were assigned to either a sham group (control, ) or sepsis group (; cecal ligature and puncture model, 24 and 48 hours after CLP). Surviving rats () were decapitated at 24 hours (early phase; ) or 48 hours (late phase; ) after CLP and kidneys removed for proteomic analysis. 2D-DIGE and DeCyder 2D software (-test, ) were used for analysis of significantly regulated protein spots. MALDI-TOF in combination with peptide mass fingerprinting (PMF) as well as Western Blot analysis was used for protein identification. Bioinformatic network analyses (STRING, GeneMania, and PCViz) were used to describe protein-protein interactions. Results. 12 spots were identified with significantly altered proteins () in the three analyzed groups. Two spots could not be identified. Four different proteins were found significantly changed among the groups: major urinary protein (MUP5), cytochrome c oxidase subunit B (COX5b), myosin-6 (MYH6), and myosin-7 (MYH7). A significant correlation with the proteins was found for mitochondrial energy production and electron transport. Conclusions. COX5B could be a promising biomarker candidate since a significant association was found during experimental sepsis in the present study. For future research, COX5B should be evaluated as a biomarker in both human urine and serum to identify sepsis.

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Preparation of High Modulus Poly(Ethylene Terephthalate): Influence of Molecular Weight, Extrusion, and Drawing Parameters

Poly(ethylene terephthalate) (PET) which is one of the most commercially important polymers, has for many years been an interesting candidate for the production of high performance fibres and tapes. In current study, we focus on investigating the effects of the various processing variables on the mechanical properties of PET produced by a distinctive process of melt spinning and uniaxial two-stage solid-state drawing (SSD). These processing variables include screw rotation speed during extrusion, fibre take-up speed, molecular weight, draw-ratio, and drawing temperature. As-spun PET production using a single-screw extrusion process was first optimized to induce an optimal polymer microstructure for subsequent drawing processes. It was found that less crystallization which occurred during this process would lead to better drawability, higher draw-ratio, and mechanical properties in the subsequent SSD process. Then the effect of drawing temperature (DT) in uniaxial two-stage SSD process was studied to understand how DT (

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Advances and Prospects in Stem Cells for Cartilage Regeneration

The histological features of cartilage call attention to the fact that cartilage has a little capacity to repair itself owing to the lack of a blood supply, nerves, or lymphangion. Stem cells have emerged as a promising option in the field of cartilage tissue engineering and regenerative medicine and could lead to cartilage repair. Much research has examined cartilage regeneration utilizing stem cells. However, both the potential and the limitations of this procedure remain controversial. This review presents a summary of emerging trends with regard to using stem cells in cartilage tissue engineering and regenerative medicine. In particular, it focuses on the characterization of cartilage stem cells, the chondrogenic differentiation of stem cells, and the various strategies and approaches involving stem cells that have been used in cartilage repair and clinical studies. Based on the research into chondrocyte and stem cell technologies, this review discusses the damage and repair of cartilage and the clinical application of stem cells, with a view to increasing our systematic understanding of the application of stem cells in cartilage regeneration; additionally, several advanced strategies for cartilage repair are discussed.

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