A survey study in diabetic subjects on the general information about diabetes mellitus, it’s social aspects, complications and treatment

2016-12-02T04-57-08Z
Source: Medicine Science | International Medical Journal
Gokhan Colpan, Merve Colpan, Canan Ersoy.
Diabetes mellitus (DM) is a metabolic disorder affecting many people worldwide, and its complications have become a global public health burden. Most diabetic patients are not aware of their conditions and the importance of the disease until complications develop, despite education programmes. This study was conducted to evaluate the general information level of diabetic patients about DM, its social aspects, treatment and complications. Patients with type 1 and 2 diabetes were enrolled in the study. A face to face questionnaire was applied to obtain patients' general information and diabetes awareness. To evaluate the overall knowledge, 40 questions were asked. In the assessment of the total scale scores (TSS), each correct answer was scored as 1 and incorrect as 0 point. The mean age of 120 participants was 42.5±15.4 years, 60.8% were females, 75% were married. The information level about the complications were statistically significantly higher in female diabetics than males. Information level about treatment of diabetes was higher in single diabetics compared to married ones. Married group had significantly higher scores concerning complications compared to single group. The results for the general information level, social aspect of diabetes, treatment and TSS were found to be statistically significantly higher in high education level group compared to low. In conclusion, education level of a patient seems to be the most prominent contributor of level of knowledge of diabetes, its complications, treatment and social aspects.


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Effect of flunarizine on memory function by using step down passive avoidance test in albino rats

2016-12-02T04-03-15Z
Source: International Journal of Basic & Clinical Pharmacology
Vinod Shinde, Radha Yegnanarayan, Khyati Doshi, Akhil Agarwal.
Background: Aim of the study was to evaluate effect of flunarizine on memory function by using step down passive avoidance test in albino rats. Methods: The study approved by IAEC was conducted using 24 albino rats (n= 6 in each group). Effect of normal saline (0.1 ml/100g), fluoxetine (10 mg/kg, intraperitoneally (ip)), and flunarizine (2 and 10 mg/kg, ip) on memory retrieval in rats was evaluated by using Step-down passive avoidance test. One day prior to conducting the test, each rat was trained to stay on central shock free zone platform (SFZ) for at least 90s. For the training, animals were applied shock of 15s every time when the rat stepped down placing all the paws on the grid floor. On the consecutive day retention of the memory was tested thirty minutes after administration of all test drugs. Step down latency (SDL) and number of mistakes was observed for a period of 5 min in all rats. Results: The data was analyzed by one-way analysis of variance (ANOVA) and Students t-test and P


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Pharmacological evaluation of substituted 4, 5-diphenyl furan-3-carboxamide compound for antidepressant activity in mice

2016-12-02T04-03-15Z
Source: International Journal of Basic & Clinical Pharmacology
Jayakumar J. K., Nityakarnam, Kishore Kumar P., Supriya.
Background: Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. Many drugs are available as effective antidepressants. But still there is necessity of developing novel compounds with minimized side effects. Hence this study was aimed to investigate the antidepressant activity of novel furan compound in albino mice. Methods: Antidepressant activity of novel furan compound was investigated by using forced swimming test (FST) and tail suspension test (TST) models. Fluoxetine was used as standard drug in this study. Results: It has been observed from our study that medium dose of test compound (10 mg/kg) reduced duration of immobility time to 35 seconds when compared to control group (147 seconds) in FST model. In TST model, the test compound of medium dose (10 mg/kg) had produced 83% protection against passive behaviour which is almost similar to standard drug fluoxetine (100%). Conclusions: The results of the specifies that compared to other two doses of test compound (5 mg/kg and 20 mg/kg), medium dose of test compound found as an effective dose for treating depression produced due to stress. However, further expansion of the study is needed for this compound to prove as a novel effective antidepressant compared to other drugs available for treating depression.


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A prospective study on adverse drug reactions reported in a tertiary referral hospital

2016-12-02T04-03-15Z
Source: International Journal of Basic & Clinical Pharmacology
Brahadeesh Mayathevar, Dhivya Thiyagarajan, Thamilarasi Soundararajan, Vallish B. N., Rizwan S. A..
Background: To determine the incidence of Adverse drug reactions in our hospital, to study the age wise distribution, the role of concurrent medication and the common drugs that are prone to cause adverse drug reactions and its seriousness. Methods: After getting prior approval from Institutional ethical committee a prospective study was done where in cases attending OPD, ward, ICU were studied over a year. A complete history was taken regarding drug exposure (dosage, date started, duration and interruptions in use), initiation of drug use and onset of reaction ,previous adverse drug reactions, improvement after decrease in dosage, disease states predisposing to eruptions, previous family and personal history of skin disease, environmental and occupational exposure to chemicals. Relevant laboratory test such as blood investigations, liver and renal function tests are carried out and results were analysed statistically by SPSS version 21 and interpretations done based on the results. Results: Incidence of ADR among OPD =0.18, IPD=1.98, OPD+IPD=0.39 /1000cases.The highest incidence of Adverse drug reactions were found among the age group of 30-39 years (27.45%), 40-49 years (23.53%), with the highest among antibiotic group of drugs (35.29%) involving a maximum duration of 2-7 days. Drug reactions mostly occurred with the oral route 66.67) and most of it requiring hospitalization (47.06%), 60.78% of reactions were manifested in skin, 58.82% of patients with ADR had concomitant medications and 19.61% had Diabetes mellitus, 90% of reactions abated after drug withdrawal with regard to its outcome 94.12% of reactions recovered. Conclusions: The study suggest the adverse drug reactions commonly occur in middle age, mostly manifesting in skin with oral route of administration ,associated with concomitant medications and it requires hospitalisation with a good recovery rate with diabetes being the common comorbid disorder.


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Escobar syndrome: non-lethal multiple pterygium syndrome case report

2016-12-02T01-57-08Z
Source: Medicine Science | International Medical Journal
Bayram Ali Dorum, Hilal Ozkan, Nilgun Koksal.
Escobar syndrome is a rare disorder that is a nonlethal variant of multiple pterygium syndromes. It is usually diagnosed in utero on fetal ultrasound and then confirmed in the neonatal period. Escobar syndrome is characterized by arthrogryposis multiplex congenita, excessive pterygia, congenital contractures, and abnormal facial appearance. It manifests as an autosomal recessive condition, and is caused by homozygous or compound heterozygous mutation of the CHRNG gene. Other variable features include growth retardation, congenital respiratory distress, ptosis, low set ears, cleft palate, and cryptorchidism. In this article, a newborn patient with Escobar syndrome was presented to share difficulties in the neonatal period, and the clinical features were discussed in the light of the literatüre.


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Electrical stimulation (ES) of the upper airway (UAW) dilator muscles for patients with obstructive sleep apnoea (OSA)

http://gsfakia.blogspot.com/2016/12/electrical-stimulation-es-of-upper.html

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Appraise the Health-Related Quality of Life among Trauma Patients

2016-12-01T16-50-10Z
Source: International Journal of Health and Rehabilitation Sciences (IJHRS)
Ravi Kant Jain, Neelesh Dhadse, Chirag Sethi, Ravindra Kumar, Susmit Kosta.
Background: Limb injures is revolve a life-changing event that can cause significant disruptions in many important areas of life. Objectives: The objective of our study was to appraise the Health Related Quality of Life (HRQOL) and psychosocial factors associated with pain and disability in patients following Upper limb (UL) and lower limb (LL) trauma patients Materials and methods: A sample of convenience 300 adult male and female patients who met the inclusion criteria was included. A short form (36) health status questionnaire was filled by a single author from each patient after one year of follow up. This part was utilized to assess the QOL among limbs traumas patients. Results: Intraclass correlation coefficients were greater than 0.7 in five of the eight domains of SF 36 except mental health, social function and general health. Chronbachs α was higher than 0.8 all the domains except in social function domain. There was no difference in Health Related Quality of Life in patients with upper and lower limb trauma. However there was significant difference in 4 domains related to physical components of SF 36 survey form between male and females. Conclusion: Both upper and lower limb trauma similarly affects the Health Related Quality of Life in all age group of patients. Keywords: Sf-36, Trauma, HRQOL


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