Δευτέρα 8 Φεβρουαρίου 2016

Sleep mediates the link between resiliency and behavioural problems in children at high and low risk for alcoholism

Summary

Children of alcoholic parents are at greater risk for developing substance use problems. Having a parent with any mental illness increases the risk for sleep disorders in children. Using actigraphy, this study characterized sleep in children of alcoholics and community controls over a period of 1 week. This study further examined whether sleep characteristics of the children mediated the relationship between self-regulation indices (i.e. undercontrol and resiliency) and outcome measures of function (e.g. problem behaviours and perceived conflict at home). Eighty-two children (53 boys, 29 girls, 7.2–13.0 years old) were recruited from the ongoing Michigan Longitudinal Study. Seventeen participants had no parental history of alcohol abuse or dependence (FH−), 43 had at least one parent who was a recovered alcoholic, and 22 had at least one parent who met diagnostic criteria within the past 3 years. Sleep was assessed with actigraphy and sleep diaries for 1 week, and combined with secondary analysis of data collected for the longitudinal study. FH− children had more objectively measured total sleep time. More total sleep time was associated with greater resiliency and behavioural control, fewer teacher-reported behavioural problems, and less child-reported conflict at home. Further, total sleep time partially mediated the relationship between resiliency and perceived conflict, and between resiliency and externalizing problems. These findings suggest that in high-risk homes, the opportunity to obtain sufficient sleep is reduced, and that insufficient sleep further exacerbates the effects of impaired dispositional self-regulatory capacity on behavioural and emotional regulation.



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Laryngeal (larynx) cancer - Recovery - The Observer Star


The Observer Star

Laryngeal (larynx) cancer - Recovery
The Observer Star
If you've had all of your larynx removed (total laryngectomy), you won't be able to speak normally, because you will no longer have vocal cords. A number of techniques can be used to replicate the functions of your vocal cords (see below), although ...



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Παρασκευή 5 Φεβρουαρίου 2016

Cutaneous Cellular Pseudoglandular Schwannoma: An Unusual Histopathologic Variant.

Cellular schwannoma and pseudoglandular schwannoma are both previously described rare variants of schwannoma. The authors present an unusual case of a cellular spindle cell neoplasm with prominent gland-like structures, having features of both variants. The nature of this lesion was confirmed by histology and immunohistochemistry, with diffuse and strong S100 and membranous collagen type IV staining. The gland-like structures were lined by S100 + cells and contained proteinaceous, mucicarmine-negative material, supporting a degenerative, not true glandular, phenomenon. This is the first case of a cutaneous schwannoma demonstrating both marked cellularity and pseudoglandular formation, which the authors have designated cutaneous cellular pseudoglandular schwannoma. Recognition of this extremely rare variant will help avoid diagnostic confusion and overtreatment of this benign entity. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

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Demens påvirker humoren

Sansen for slapstick-humor øker hos pasienter med demens.

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Hypoxic markers in non-small cell lung cancer (NSCLC) – A review

Surgery, chemotherapy and radiotherapy have been the main pillars of cancer treatment. Some of the recent improvements in survival of other cancers can be attributed to novel treatment therapies. Such therapies mostly target specific molecules involved in cancer progression and metastasis. Development and clinical introduction of targeted therapies involve identification of new and potentially important molecules in cancer progression. The next important step is to evaluate its prognostic value. Prognostication by molecular markers is also important as this may identify subgroups of patients in need for additional treatment or not, which was not possible with the traditional clinic-pathological prognosticators. Hypoxic markers have been widely explored in the recent past for their prognostic efficacy in non-small cell lung cancer.

The present review article will enlighten importance of hypoxic markers with special reference to non-small cell lung carcinoma.

L'articolo Hypoxic markers in non-small cell lung cancer (NSCLC) – A review sembra essere il primo su European Review.



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Is the effect of topical intranasal steroids on obstructive adenoids transient or long-lasting? Case series and systematic review of literature

Research Articles
M A Bitar, J Nassar, R Dana
The Journal of Laryngology & Otology,FirstView Article(s), 6 pages

Abstract
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Transoral robotic resection of a large schwannoma in the retropharyngeal space

Rapid Communication
A Gungadeen, R Lisseter, J Manickavasagam, V Paleri
The Journal of Laryngology & Otology,FirstView Article(s), 3 pages

Abstract
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