The objective of this study was to report the clinical evaluation results and 3D dental and craniofacial characteristics observed in two male patients with mucopolysaccharidosis type II (MPS-II). The patients were evaluated clinically (soft tissue evaluation, occlusion, periodontal and dental examination) and by craniofacial computed tomography (CT), with evaluation of 3D images in ITK-Snap and 3D Slicer® software. Mandibular 3D volumetric label maps were built from CT scans of both patients and compared through superimposition to a healthy patient's mandibular images.
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