Aspergillus in chronic lung disease: Modeling what goes on in the airways

<span class="paragraphSection"><div class="boxTitle">Abstract</div><span style="font-style:italic;">Aspergillus</span> species cause a range of respiratory diseases in humans. While immunocompromised patients are at risk for the development of invasive infection with these opportunistic molds, patients with underlying pulmonary disease can develop chronic airway infection with <span style="font-style:italic;">Aspergillus</span> species. These conditions span a range of inflammatory and allergic diseases including <span style="font-style:italic;">Aspergillus</span> bronchitis, allergic bronchopulmonary aspergillosis, and severe asthma with fungal sensitization. Animal models are invaluable tools for the study of the molecular mechanism underlying the colonization of airways by <span style="font-style:italic;">Aspergillus</span> and the host response to these non-invasive infections. In this review we summarize the state-of-the-art with respect to the available animal models of noninvasive and allergic <span style="font-style:italic;">Aspergillus</span> airway disease; the key findings of host-pathogen interaction studies using these models; and the limitations and future directions that should guide the development and use of models for the study of these important pulmonary conditions.</span>

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