Short stature, insufficient annual height growth and back bone age: Nutritional growth retardation or growth hormone deficiency?

2016-10-25T16-48-08Z
Source: Journal of Contemporary Medicine
Oya Balcı Sezer, Derya Buluş.
Objective: Serum insulin-like growth factor 1 (IGF-1) concentrations are affected both by nutritional status and serum growth hormone levels, therefore IGF-1 is useful as an indicator of growth and nutritional status. The aim of this study is to determine the cut-off level of IGF-1 to differentiate nutritional growth retardation (NGR) from growth hormone deficiency (GHD) in children with insufficient annual height growth and back bone age. Design: The study group included 57 children who had been diagnosed with NGR due to malnutrition and 36 children with similar age and sex, who had been diagnosed with short stature due to GHD. Serum free IGF-1 concentrations were determined by chemiluminescent immunometric assay in all children. Results: There was no significant difference in serum IGF-1 levels between NGR and GHD groups (p> 0.05). We could not find a statistically significant cut-off level for IGF-1 to differentiate children with NGR from children with GHD. Conclusions: We suggest that examination of IGF-1 levels in children with NGR to exclude GHD is not useful.


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