Immunohistochemical Expression of Leptin (Ob-protein) in Experimentally Hypertensive Rat Kidney Tissues

2016-10-25T16-48-08Z
Source: Journal of Contemporary Medicine
Fikret Gevrek, Meral Öncü, Kanat Gülle, Dilek Bayram, Erdal Karaöz.
Objective: Leptin is an ob gene protein which has a 16 kDa weight. The aim of this study is to determine immunohistochemically the correlation between immunohistochemical expression of Leptin and hypertension in rat kidney tissues. Material and Methods: Wistar albino adult rats were divided into control and experiment groups, with six rats in each. L-NAME was given to the experiment group. The kidneys of all rats were excised surgically. After these kidneys were subjected to routine histologic and immunohistochemical processes, microscopic analyses were performed. Results: The blood pressure levels of the experimental group were higher than in the control, and their renal tissues had some distinctive histopathological changes. Additionally, Leptin immunostaining scores increased in the excretory tubule cells of hypertensive rats. Conclusion: Upregulation of Leptin expression may indicate that Leptin molecules have an important physiological role such as regulation of some kidney functions to adapt high blood pressure; or, contrary to this, they may be a pathophysiological sign. Further research is necessary to determine whether this situation is physiological or pathophysiological process.


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