High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing [Biophysics and Computational Biology]

Myosins adjust their power outputs in response to mechanical loads in an isoform-dependent manner, resulting in their ability to dynamically adapt to a range of motile challenges. Here, we reveal the structural basis for force-sensing based on near-atomic resolution structures of one rigor and two ADP-bound states of myosin-IB (myo1b)...

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