COX-2 inhibitors may reverse IDO1-mediated immunosuppression in some cancers

In preclinical studies, tumours that consitutively expressed the protein indoleamine 2,3-dioxygenase (IDO1) responded to the cyclooxygenase-2 (COX-2) inhibitor celecoxib (celebrex) and had improved infiltration of certain subsets of T cells, making them...

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