Angular measurements of the dynein ring reveal a stepping mechanism dependent on a flexible stalk [Biophysics and Computational Biology]

The force-generating mechanism of dynein differs from the force-generating mechanisms of other cytoskeletal motors. To examine the structural dynamics of dynein’s stepping mechanism in real time, we used polarized total internal reflection fluorescence microscopy with nanometer accuracy localization to track the orientation and position of single motors. By measuring the...

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