Polyfunctionality of bona fide resident lung CD69+ natural killer cells

We read with great interest the recent article from Marquardt et al1 dedicated to the detailed characterization of human lung natural killer (NK) cells. On the basis of the expression of CD69, they nicely distinguished bona fide resident CD69+ from circulating CD69− CD56dim NK cells in a large cohort of patients undergoing pulmonary lobectomy. They have shown that NK cells in the lung are highly differentiated and predominantly circulating ones, which contrasts with lung CD3+ T cells.

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