IL-10 Overexpression Predisposes to Invasive Aspergillosis by Suppressing Antifungal Immunity

We show that the genetically-determined overexpression of IL-10 is a risk factor for invasive aspergillosis after stem-cell transplantation. Our results identify an IL-10-mediated mechanism that regulates the balance between anti- and proinflammatory antifungal immunity.

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