Classification Systems in Gestational Trophoblastic Neoplasia - Sentiment or Evidenced Based?

The main factor that has driven the development of a classification system for GTN is to identify, at the point of diagnosis, which patients will not respond to single-agent chemotherapy treatment. This is extremely important to guide subsequent management, and ensure that patients are treated with the most appropriate first line regimen, highlighting those who are likely to need more intensive therapy [1]. However, the classification of GTN has historically proven highly controversial, and prior to the combination of the FIGO and WHO classification system in 2000, multiple classification systems were used throughout the world [2].

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