Publication date: Available online 28 February 2017
Source:Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Author(s): Marco Antonio Briones-Orta, S. Eréndira Avendaño-Vázquez, Diana Ivette Aparicio-Bautista, Jason D. Coombes, Georg F. Weber, Wing-Kin Syn
Osteopontin (OPN) is an extracellular matrix protein that is overexpressed in various cancers and promotes oncogenic features including cell proliferation, survival, migration, and angiogenesis, among others. OPN can participate in the regulation of the tumor microenvironment, affecting both cancer and neighboring cells. Here, we reviewed the roles of OPN splice variants (a, b, c) in cancer development, progression, and prognosis, and also discussed the identities of isoforms 4 and 5. We also discussed how single-nucleotide polymorphisms (SNPs) of the OPN gene are an additional factor influencing the level of OPN in individuals, modulating the risks of cancer development and outcome.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2lxKlaA
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Introduction Crisis management is a critical organizational function. Failure can result in serious harm to stakeholders, losses for an orga...
-
Maritime Logistics • General Ship Knowledge • Seaborne Cargoes and Dangerous Goods • Cargo Planning • Marine Terminal Operations • Modal and...
-
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o7K1Dm via IFTTT
-
You know the feeling: you're hanging out somewhere, you look across the room, and suddenly your stomach drops. You start to sweat. Your ...
-
Before you begin to write a comparison essay, you should go through a a few simple steps. 50 Compare and Contrast Topics. Search the site GO...
-
AP ® United States Government and Politics 2014 Free-Response Questions © 2014 The College Board. College Board, Advanced Placement Program,...
-
Free fundraising ideas for raising money for your charity, cause or school by shopping online with your favourite retailers such as Amazon ...
-
Unit 5: Writing cohesively - Section index. This unit looks at the use of language strategies to create clear, cohesive writing. It shows yo...
-
918 quotes have been tagged as self-confidence: Edgar Allan Poe: ‘I have great faith in fools - self-confidence my friends will call it.’, R...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου