[Perspectives] What Archie Cochrane learnt from a single case

The 18th-century physician Marcus Herz held that case reports were the means by which doctors “write experience into the world”. In broad terms they record how the diverse phenomena of illness are made sense of medically and which treatments are tried. But the search for explanations can prove elusive and case reports instead may revolve around clinical uncertainty and irresolution. Although today's case reports often follow standard approaches to medical problems, some feature novel situations that may confound readers' expectations.

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