Functional importance of stripping in NF{kappa}B signaling revealed by a stripping-impaired I{kappa}B{alpha} mutant [Biophysics and Computational Biology]

Stress-response transcription factors such as NFκB turn on hundreds of genes and must have a mechanism for rapid cessation of transcriptional activation. We recently showed that the inhibitor of NFκB signaling, IκBα, dramatically accelerates the dissociation of NFκB from transcription sites, a process we have called “stripping.” To test the...

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