Multifunctional near-infrared dye-magnetic nanoparticles for bioimaging and cancer therapy

Publication date: 1 April 2017
Source:Cancer Letters, Volume 390
Author(s): Xiaoyang Hou, Huige Zhou, Liming Wang, Jianqin Tang, Chunying Chen, Guan Jiang, Yanqun Liu
Theranostics based on nanoparticles have developed rapidly in the past decade and have been widely used in the diagnosis and treatment of liver cancer, breast cancer, and other tumors. However, for skin cancers, there are limited studies. In the present study, we successfully synthesized a theranostic nanoparticle by grating IR820 onto the surface of chitosan-coated magnetic iron oxide, IR820-CS-Fe3O4, showing an excellent magnetic resonance imaging (MRI) capability and cytotoxic effects against melanoma under irradiation with a near-infrared (NIR) laser (808 nm) in vitro. Furthermore, good stability for up to 8 days and negligible cytotoxicity were observed. These characteristics are important for biomedical applications of nanoparticles. In conclusion, we provide a novel and potential theranostic platform for melanoma treatment and detection.



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