Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5 [Medical Sciences]

Mutations in the p53 tumor suppressor gene are the most frequent genetic alteration in cancer and are often associated with progression from benign to invasive stages with metastatic potential. Mutations inactivate tumor suppression by p53, and some endow the protein with novel gain of function (GOF) properties that actively promote...

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