Castration is the standard therapeutic treatment for advanced prostate cancer but with limited benefit due to the profound relapse and metastasis. Activation of inflammatory signaling pathway and initiation of epithelial-mesenchymal transition (EMT) are closely related to drug resistance, tumor relapseas well as metastasis. In this study, we demonstrated that metformin is capable of inhibiting prostate cancer cell migration and invasion by repressing EMT evidenced by downregulating the mesenchymal markers N-cadherin, Vimentin, and Twist and upregulating the epithelium E-cadherin.
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Summary We tested whether prophylactic droperidol and ondansetron, in combination with a moderate dose of dexamethasone, were equally effe...
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by Rita Rey-Baños, Luis E. Sáenz de Miera, Pedro García, Marcelino Pérez de la Vega Retrotransposons with long terminal repeats (LTR-RTs) a...
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by Demin Li, Carol Bentley, Jenna Yates, Maryam Salimi, Jenny Greig, Sarah Wiblin, Tasneem Hassanali, Alison H. Banham Therapeutic monoclon...
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Web version of a book about Subversion. Work in progress, however already very complete. The book should be published by O'Reilly and As...
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by Kerstin Jost, Isabelle Pramana, Edgar Delgado-Eckert, Nitin Kumar, Alexandre N. Datta, Urs Frey, Sven M. Schulzke Background Poor contro...
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Abstract Background Head and neck extirpations requiring reconstruction are challenging surgeries with high postoperative complication r...
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Through the Wormhole: Is There an Edge to... Science - 43 min - ★ It is commonly theorized that the universe began with the Big Bang... Thro...
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