Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide [Neuroscience]

Major depressive disorder (MDD) is a substantial burden to patients, families, and society, but many patients cannot be treated adequately. Rodent experiments suggest that the neuropeptide galanin (GAL) and its three G protein-coupled receptors, GAL1–3, are involved in mood regulation. To explore the translational potential of these results, we assessed...

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