Effect of petroleum ether extract of Cedrus deodara on body weight in diabetic rats

Ganesh Pradhan, Suparna Podder, Sushil Charndra Mahapatra

International Journal of Clinical and Experimental Physiology 2016 3(3):140-143

Background and Aim: Overweight and obesity are the strong risk factors for diabetes. The present study aims to find out whether petroleum ether extract of Cedrus deodara (PEECD) reduces body weight in alloxan-induced diabetic rats. Materials and Methods: A total of 36 rats (6 normal rats and 30 alloxan-induced diabetic rats) were included in the study and they were divided into six groups of six animals each. PEECD at three different doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg was administered on 0th, 7th, 14th, and 21st days and then the body weight was estimated using a weighing machine. Statistical analysis was performed by one-way ANOVA. Results: On the 14th and 21st days of PEECD administration at doses of both 200 mg/kg and 400 mg/kg, the body weight decreased significantly (P < 0.05) in alloxan-induced diabetic rats when compared with the control group. However, this decrease in body weight was also statistically significant (P < 0.05) when compared with the standard on the 21st day of PEECD administration at a dose of 400 mg/kg. There was a statistically significant decrease (P < 0.05) in body weight when compared with the control group on the 21st day of administration of PEECD at a dose of 100 mg/kg. Conclusion: From the above findings, we conclude that PEECD is capable of reducing body weight in alloxan-induced diabetic rats. Hence, further studies should be done to confirm the weight-reducing property of PEECD extract on diabetic rats so that it could be added to the list of traditional plants which are effective in reducing the body weight.

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