Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-κB/STAT3 signaling cascade

• A new mechanism for gemcitabine resistance via stemness induction is proposed.• Gemcitabine induces pancreatic CSCs and stemness-associated genes.• Gemcitabine enhances cell migration, chemoresistance, and tumorigenesis.• STAT3 pathway partially mediates gemcitabine-induced CSC properties and tumor relapse.• Nox/ROS/NF-κB participates in gemcitabine-induced STAT3 activation and stemness.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2br3kTk
via IFTTT