Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons

Abstract

Immune activation in human immunodeficiency virus (HIV) is a well described phenomenon. We found that HIV patients have higher secretion of interferon (IFN)-γ compared with non-HIV subjects, as measured by the “nil” value in the QuantiFERON-TB Gold test, even when viral loads are low. This may reflect ongoing immune activation, even with optimal HIV management.

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