Reply to Liu et al.: Haplotype matters: CD226 polymorphism as a potential trigger for impaired immune regulation in multiple sclerosis [Biological Sciences]

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, which results from a breakdown in peripheral tolerance driven by genetic and environmental factors. The activating receptor DNAM-1 (DNAX accessory molecule-1, CD226) seems to be crucial in both NK-cell (1) and Foxp3+ (forkhead box protein-3) regulatory T-cell (Treg)...

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