Remodelling of Myocardial Intercalated Disc Protein Connexin 43 Causes Increased Susceptibility to Malignant Arrhythmias in ARVC/D Patients

Sudden cardiac death (SCD) is a main cause of death in young people. In European and North American populations, approximately 50 to 100 people per 100,000 die of SCD each year [1]. Half of these deaths are attributed to malignant ventricular arrhythmias [2]. Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is the leading cause of SCD in young people and athletes [3]. It is a primary cardiomyopathy with a main manifestation of fibrofatty replacement and ventricular arrhythmias and an incidence rate ranging from 1/1000 to 1/5000 [4].

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