Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer [Biophysics and Computational Biology]

The expertise of protein kinases lies in their dynamic structure, wherein they are able to modulate cellular signaling by their phosphotransferase activity. Only a few hundreds of protein kinases regulate key processes in human cells, and protein kinases play a pivotal role in health and disease. The present study dwells...

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