Direct measurement of sequence-dependent transition path times and conformational diffusion in DNA duplex formation [Biophysics and Computational Biology]

The conformational diffusion coefficient, D, sets the timescale for microscopic structural changes during folding transitions in biomolecules like nucleic acids and proteins. D encodes significant information about the folding dynamics such as the roughness of the energy landscape governing the folding and the level of internal friction in the molecule,...

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